Gigp-40.mp4 (2027)

-related research (such as cell-level studies or related data).

The enzyme PYGL-1 is necessary for this metabolic flexibility. GIGP-40.mp4

Glycogen serves as a direct fuel source to sustain glycolytic plasticity and synaptic function in vivo. The inability to utilize GDGP is associated with deficiencies in synaptic vesicle recycling during hypoxia. -related research (such as cell-level studies or related

This paper explores the role of glycogen as a metabolic fuel source within neurons, specifically focusing on Glycogen-Dependent Glycolytic Plasticity (GDGP). Recent studies using sensors like HYlight in models such as Caenorhabditis elegans have identified that neurons can utilize glycogen to regulate glycolytic states during periods of high activity or transient hypoxia. This study highlights the essential role of PYGL-1, an ortholog of human glycogen phosphorylase, in sustaining this plasticity. Introduction an ortholog of human glycogen phosphorylase