As a modern retailer, Lowe's maintains handicap-accessible restrooms to accommodate all customers.
In summary, you can confidently rely on finding a bathroom when visiting a Lowe's store.
If you're asking because you're planning a project, I can help you find: in stock. Store hours for a location near you.
Restrooms are typically situated near the front of the store, often close to the customer service desk or the exit for easy access [1].
While intended for customers, Lowe's generally allows shoppers to use their restrooms during normal business hours.