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: The research tracks how certain mutations (like the L398P variant) affect the protein's breakdown when exposed to ATRA/Arsenic Trioxide (ATO) combination treatments.

: It examines the ability of the mutant proteins to exchange nuclear co-repressors for co-activators, which is a critical factor in how the body responds—or fails to respond—to therapy.

If this is the scientific context you are looking for, the primary features related to this data include: 24010.rar

ligand-binding domain (LBD) , which can compromise how well treatments bind to the oncogene.

oncogene, which is frequently associated with scientific data papers indexed by the code . : The research tracks how certain mutations (like

: This specific data (prot.24010) details the molecular consequences of resistance to All-Trans Retinoic Acid (ATRA) , a standard treatment for APL. RAR

Mutations : The study focuses on mutations localized to the RAR and Bioinformatics | Protein Science Journal

Structure, Function, and Bioinformatics | Protein Science Journal